Product Information
Name:Histone deacetylase inhibitor VIII
Synonyms:
- CAY10603N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester
- carbamic acidBML-281
Brand:Biosynth
Description:Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:446.21653
Formula:C22H30N4O6
Purity:Min. 95%
Color/Form:White To Off-White Solid
Technical inquiry about: Histone deacetylase inhibitor VIII
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