5-Methyl-3-phenylisoxazole-4-carboxylic acid

CAS: 1136-45-4

Ref. 3D-FM165289

Product Information

• Name: 5-Methyl-3-phenylisoxazole-4-carboxylic acid
• Synonyms: 3-Phenyl-5-methylisoxazole-4-carboxylic acid, 4-Carboxy-5-methyl-3-phenylisoxazole, 4-Isoxazolecarboxylic acid, 5-methyl-3-phenyl-, 5-Methyl-3-Phenyl-1,2-Oxazole-4-Carboxylic Acid, 5-Methyl-3-phenyl-4-isoxazolecarboxylic acid, NSC 76870, PMI-acid
• CAS: 1136-45-4

Description

5-Methyl-3-phenylisoxazole-4-carboxylic acid (5MPIA) is a potent inhibitor of the acylation reaction. It has been shown to be an effective corrosion inhibitor for the corneal surface and organic solvents. 5MPIA also appears to have anti-inflammatory properties and was shown to inhibit virus replication in cell culture. The optimum concentration of this agent is 2 mM, at which it has a half maximal inhibitory concentration (IC50) of 0.34 mM. 5MPIA has been studied as a possible treatment for inflammatory diseases such as psoriasis and rheumatoid arthritis. This compound is structurally similar to other inhibitors, such as 3-(4′-methylphenoxy)propionic acid and 3-(4′-chlorophenoxy)propionic acid. 5MPIA has been tested in clinical trials for the treatment of psoriasis and rheumatoid arthritis with promising results.

• Brand: Biosynth

Chemical properties

• Molecular weight: 203.19 g/mol
• Formula: C₁₁H₉NO₃
• Purity: Min. 95%
• InChI: InChI=1S/C11H9NO3/c1-7-9(11(13)14)10(12-15-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)
• InChI key: InChIKey=PENHKTNQUJMHIR-UHFFFAOYSA-N
• SMILES: Cc1onc(-c2ccccc2)c1C(=O)O