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2-Methylthiopyrimidine-4,6-diamine
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2-Methylthiopyrimidine-4,6-diamine

CAS: 1005-39-6

Ref. 3D-FM35226

10g
118.00 €
25g
204.00 €
Estimated delivery in United States, on Monday 22 Apr 2024

Product Information

Name:
2-Methylthiopyrimidine-4,6-diamine
Synonyms:
  • 2-(Methylsulfanyl)Pyrimidine-4,6-Diamine
  • 2-(Methylthio)-4,6-pyrimidinediamine
  • 2-(Methylthio)Pyrimidine-4,6-Diamine
  • 2-Methylsulfanylpyrimidine-4,6-diamine
  • 2-Methylthio-4,6-diaminopyrimidine
  • 4,6-Diamino-2-(methylmercapto)pyrimidine
  • 4,6-Diamino-2-(methylthio)pyrimidine
  • 4,6-Pyrimidinediamine, 2-(methylthio)-
  • NSC 44919
  • NSC 60555
  • See more synonyms
  • Pyrimidine, 4,6-diamino-2-(methylthio)-
Description:

2-Methylthiopyrimidine-4,6-diamine is a potent inhibitor of the enzyme DNA polymerase. It has shown to be effective against hepg2 cells and other cancer cells. The compound binds covalently to the active site of the enzyme, where it stabilizes the transition state and deshields the electrostatic field around the nucleophilic nitrogen atom. This interaction leads to a decreased affinity for ATP, which is required for DNA synthesis. 2-Methylthiopyrimidine-4,6-diamine also has antimalarial activity and inhibits amide bond formation in hepg2 cells.

Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
156.21 g/mol
Formula:
C5H8N4S
Purity:
Min. 95%
InChI:
InChI=1S/C5H8N4S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3,(H4,6,7,8,9)
InChI key:
InChIKey=AHAIUNAIAHSWPG-UHFFFAOYSA-N
SMILES:
CSc1nc(N)cc(N)n1
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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