Product Information
- (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2]dihydroxyplatinum
- Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′]dihydroxy-, (SP-4-2)-
- 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-
- Platinum, (1,2-cyclohexanediamine-κN,κN′)dihydroxy-, [SP-4-2-(1R-trans)]-
- Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2]dihydroxy-, (SP-4-2)-
Oxaliplatin impurity B is a chromatographic impurity of oxaliplatin, a cytotoxic drug used to treat colorectal cancer. It is found in commercial preparations of the drug as a result of incomplete purification. Oxaliplatin impurity B is an intermediate in the synthesis of oxaliplatin, which is obtained by reacting potassium dichromate with diamine and triethylenetetramine. This product can be purified by recrystallization from water or ethanol and has been shown to have stability at pH 6-8.