Suc-Ala-Phe-Pro-Phe-pNA
CAS: 128802-73-3
Ref. 3D-FS110764
| 10mg | 266.00 € | ||
| 25mg | 500.00 € | ||
| 50mg | 737.00 € | ||
| 100mg | 1,206.00 € | ||
| 250mg | 2,624.00 € |
Product Information
- Suc-ala-phe-pro-phe-pna
- Suc-apppa
- N-(3-carboxypropanoyl)-L-alanyl-L-phenylalanyl-Nalpha-(4-nitrophenyl)-N-[(2S)-pyrrolidin-2-ylcarbonyl]-L-phenylalaninamide
Suc-Ala-Phe-Pro-Phe-pNA is a recombinant isomerase that has been shown to be an immunosuppressive agent. It is able to catalyze the conversion of cyclosporin A into its two inactive forms, as well as the conversion of cyclophilins A and B into their corresponding inactive forms. The enzyme has also been shown to have chaperone activity. Suc-Ala-Phe-Pro-Phe-pNA has been expressed in Escherichia coli and purified from inclusion bodies using an affinity column with immobilized recombinant cyclophilin A and B. The enzyme's activity was measured by catalysis of the conversion of pNPP, a substrate analogue, into pNPPdG, which can be detected spectrophotometrically at a wavelength of 340 nm. Suc-Ala-Phe-Pro-Phe-pNA shows exponential growth in the presence of
Chemical properties
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