(D-Trp6)-LHRH pamoate salt

CAS: 124508-66-3

Ref. 3D-FT109737

Product Information

• Name: (D-Trp6)-LHRH pamoate salt
• Synonyms: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 pE-HWSY(dW)LRPG-NH2
• Brand: Biosynth
• Description: The hormone LHRH is a decapeptide that stimulates the production of gonadotropins, which stimulate the synthesis and release of sex hormones. LHRH has been used for the treatment of prostate cancer. It can be administered in the form of a long-acting ester formulation, such as the pamoate salt (Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly), or as an analog, such as triptorelin acetate. The analogs are more potent than LHRH and have greater efficacy in preventing tumor growth and inducing regression. Analogs may be administered in microcapsules for extended release or orally to provide higher levels of drug at target sites. The ester linkages between amino acids allow for a sustained release of LHRH over time. These esters are hydrolyzed by enzymes present in plasma and tissues, releasing active LHRH into circulation that binds

Chemical properties

• Molecular weight: 1,311.45 g/mol
• Formula: C₆₄H₈₂N₁₈O₁₃·xC₂₃H₁₆O₆
• Purity: Min. 95%