6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one

CAS: 6809-52-5

Ref. 3D-FT28035

Product Information

• Name: 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
• Synonyms: Teprenone,, (5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one, 5,9,13,17-Nonadecatetraen-2-one, 6,10,14,18-tetramethyl-, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers, E 0671, E 36U31, Geranylgeranylacetone, Selbex, Teprenona, Teprenona [INN-Spanish], Teprenonum, Teprenonum [INN-Latin], Unii-S8S8451A4O

Description

6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one is a zirconium oxide and in vitro it has been shown to inhibit the toll-like receptor 4 (TLR4) signaling pathway. This inhibition blocks the activation of NF-κB and MAPKs by TLR4 ligands. It also inhibits inflammatory responses in a mouse model of colitis. 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one has been shown to be an effective inhibitor for polypeptide chain elongation by blocking the activity of bacterial DNA polymerase. In addition to this inhibition it also inhibits axonal growth in mice with spinal cord injury. The optimum concentration range for 6,10,14,18-tetramethyl 5 9 13 17 nonadecatetraen 2 one is

• Brand: Biosynth

Chemical properties

• Molecular weight: 330.55 g/mol
• Formula: C₂₃H₃₈O
• Purity: Min. 95%
• InChI: InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
• InChI key: InChIKey=HUCXKZBETONXFO-NJFMWZAGSA-N
• SMILES: CC(=O)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CCC=C(C)C