Temafloxacin

CAS: 108319-06-8

Ref. 3D-FT30403

Product Information

• Name: Temafloxacin
• Synonyms: 1-(2,4-Difluorophenyl)-6-Fluoro-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid, 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 3-Quinolinecarboxylic acid, 1,4-dihydro-1-(2,4-difluorophenyl)-6-fluoro-7- (3-methyl-1-piperazinyl)-4-oxo-, 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, A 62254, A 63004, Brn 4301726, Ccris 6303, T 1258, Teflox, Temac, Temafloxacin [INN:BAN], Temafloxacina, Temafloxacina [Spanish], Temafloxacine, Temafloxacine [French], Temafloxacinum, Temafloxacinum [Latin], Unii-1Wz12Gtt67

Description

Temafloxacin is a broad-spectrum fluoroquinolone antibacterial agent that is used in the treatment of pulmonary, urinary tract, and soft tissue infections. Temafloxacin inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. It has been shown to inhibit growth of gram-positive bacteria, such as Streptococcus pneumoniae, Enterococcus faecalis, and Staphylococcus aureus. This drug also has inhibitory properties against gram-negative bacteria such as Escherichia coli. Temafloxacin binds to the 50S ribosomal subunit of bacterial cells by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.
Temafloxacin has been found to be toxic to experimental animals at high doses (

• Brand: Biosynth

Chemical properties

• Molecular weight: 417.38 g/mol
• Formula: C₂₁H₁₈F₃N₃O₃
• Purity: Min. 95%
• InChI: InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
• InChI key: InChIKey=QKDHBVNJCZBTMR-UHFFFAOYSA-N
• SMILES: CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1