Product Information
- Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone
Z-VDVAD-FMK is a mouse monoclonal antibody that binds to the Mcl-1 protein and induces mitochondrial membrane depolarization. This process leads to apoptosis and neuronal death. Z-VDVAD-FMK has been shown to be effective against metastatic colorectal cancer cells in an experimental model system. Mcl-1 is an antiapoptotic protein that blocks the release of cytochrome c from mitochondria and activates NF-κB, which prevents cell death. The binding of this drug to Mcl-1 can lead to neuronal death by inhibiting the release of cytochrome c from mitochondria and activating apoptosis pathways. Z-VDVAD-FMK also has neurotrophic effects on neural cells that may be due to its ability to induce the expression of neurotrophic factors such as nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF).
Chemical properties
Technical inquiry about: 3D-KIA34492 Z-VDVAD-FMK
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