![(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione](https://static.cymitquimica.com/products/3D/img/LDA63962.png "Click to enlarge")
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS: 86639-62-5
Ref. 3D-LDA63962
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Product Information
- 9-Nitrocamptothecin (Rubitecan)
4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline (EHNQ) is a potent antitumor agent that inhibits the growth of solid tumours by inducing apoptosis. EHNQ induces apoptosis through a caspase dependent pathway and triggers DNA damage. This drug has been shown to have potent anti-tumor activity in both bone cancer and subcutaneous tumors in mice. This compound also showed an increased antitumor response when used in combination with other chemotherapy drugs such as mitomycin C and vincristine sulfate. EHNQ has been shown to cause histological changes in the liver of animals treated with higher doses, but no such effects were observed at lower doses.
Chemical properties
Technical inquiry about: 3D-LDA63962 (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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