5-Chloro-2',3'-O-isopropylidenecytidine

Ref. 3D-NC04761

Product Information

• Name: 5-Chloro-2',3'-O-isopropylidenecytidine
• Synonyms: 5-Chloro-2',3'-O-isopropylidene-D-cytidine
• Brand: Biosynth
• Description: 5-Chloro-2',3'-O-isopropylidenecytidine is a synthetic nucleoside that is activated by phosphorylation to form the corresponding nucleotide. It has antiviral and anticancer properties, and can be used as a building block for synthesis of other nucleosides. 5-Chloro-2',3'-O-isopropylidenecytidine is synthesized from 2,4-dichlorophenoxyacetic acid (DCA) and 2,5-dichloroaniline in the presence of sodium cyanide. The compound was first synthesized in 1972 and its chemical structure was determined in 1974. 5-Chloro-2',3'-O-isopropylidenecytidine has been shown to inhibit DNA synthesis by binding to viral diphosphate and deoxyribonucleosides. This compound also inhibits the activity of bacterial DNA gyrase and DNA top

Chemical properties

• Molecular weight: 317.73 g/mol
• Formula: C₁₂H₁₆ClN₃O₅
• Purity: Min. 95%
• InChI: InChI=1S/C12H16ClN3O5/c1-12(2)20-7-6(4-17)19-10(8(7)21-12)16-3-5(13)9(14)15-11(16)18/h3,6-8,10,17H,4H2,1-2H3,(H2,14,15,18)/t6-,7+,8?,10-/m1/s1
• InChI key: InChIKey=PHVNOARWMFWTCA-KIUGWDQWSA-N
• SMILES: CC1(C)OC2[C@@H](O1)[C@@H](CO)O[C@H]2n1cc(Cl)c(N)nc1=O