7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 101515-08-6

Ref. 3D-ND157323

Product Information

• Name: 7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution
• Synonyms: 7-Deaza-dGTP.Li, 2'-Deoxy-7-deazaguanosine triphosphate, 2'-Deoxy-7-deaza-GTP, 7-Deaza-2'-deoxyguanosine triphosphate, 7-Deaza-2'-dgtp, C7-Gdtp, 4H-Pyrrolo(2,3-d)pyrimidin-4-one, 2-amino-7-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)-1,7-dihydro-, 2-amino-7-[2-deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-beta-D-erythro-pentofuranosyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Description

7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt is a nucleoside analog that inhibits telomerase. It binds to the catalytic subunit of telomerase, which is an RNA-dependent DNA polymerase that synthesizes telomeres during DNA replication. This binding prevents the enzyme from extending the 3' end of the DNA strand, inhibiting cell proliferation and leading to apoptosis. Telomerase inhibition has been shown to have an inhibitory effect on insulin resistance in mice. 7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt also inhibits protein kinases, but does not inhibit phosphatases or other enzymes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 506.19 g/mol
• Formula: C₁₁H₁₇N₄O₁₃P₃·xLi
• Purity: Min. 95%