Product Information
- 20: PN: WO2009007746 SEQID: 20 unclaimed protein
- 26: PN:US20030148449 SEQID: 26 unclaimed protein
- 30: PN: WO2008086069 SEQID: 30unclaimed protein
- 3: PN:WO0194411 TABLE: 1 claimed protein
- 3: PN: WO2008137673 PAGE: 4 unclaimedsequence
- (Ala1)-Par-4 (1-6) (Mouse)
H-Ala-Tyr-Pro-Gly-Lys-Phe-OH is a peptide that activates toll-like receptor 4 (TLR4). It is a potent inhibitor of the enzyme phospholipase A2 and has been shown to inhibit the production of proinflammatory cytokines, such as IL1β, IL6, IL8, and TNFα. This peptide also has anti-inflammatory effects on autoimmune diseases, such as rheumatoid arthritis. H-Ala-Tyr-Pro-Gly-Lys-Phe-OH has been shown to inhibit prostate cancer cell growth in vitro and in vivo. It appears to exert its action by interfering with the transcriptional process at the level of RNA polymerase II. The mechanism may involve inhibition of the activation of basic fibroblast cells or suppression of epidermal growth factor signaling. H-Ala-Tyr - Pro - Gly - Lys - Phe -
Chemical properties
Technical inquiry about: 3D-PAR-3939-PI H-Ala-Tyr-Pro-Gly-Lys-Phe-OH
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