Product Information
- 2,4-Piperidinedione, 6-phenyl-
- 6-Phenylpiperidine-2,4-dione
6-Phenylazaperhydroine-2,4-dione is an analog of azaperhydroine-2,4-dione that is synthesised by the addition of a phenyl group to the alpha carbon. This compound has been shown to inhibit the growth of mycobacteria in vitro and in vivo. It also shows high antimycobacterial activity against strains of Mycobacterium tuberculosis and Mycobacterium avium complex. 6-Phenylazaperhydroine-2,4-dione inhibits mycobacterial DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. The compound is also enantiopure and optically pure, with a dieckmann geometry.
6-Phenyl
Chemical properties
Technical inquiry about: 3D-TEA26404 6-Phenylazaperhydroine-2,4-dione
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