Product Information
- Amyloid .beta.-Protein (40-1)
- H-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp-OH
Amyloid-β (Aβ) is a globular protein of about 40 amino acids that is the major constituent of amyloid plaques. Aβ is derived from sequential proteolytic processing of amyloid precursor protein (APP) by enzymes called β-secretase and γ-secretase. The Aβ1-40 fragment has been implicated in Alzheimer's disease, and its production can be inhibited by antibodies.
The fragment consists of 40 amino acids and contains a central region that shares sequence similarity with the immunoglobulin fold, flanked on either side by β-strands.
The N terminus is hydrophobic while the C terminus is hydrophilic.
It has been shown to form ion channels in lipid bilayers, which can be blocked by various ligands such as antibodies or peptides.
CAS No.: 144409-99-4
Chemical properties
Technical inquiry about: 3D-UFA40999 Amyloid ²-Protein Fragment 40-1
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