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1, 5-Dicaffeoylquinic acid can mediate glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.
1,5-Dicaffeoylquinic Acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 μmol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.
1,5-Dicaffeoylquinic acid (1,5-DQA), a caffeoylquinic acid derivative isolated from Aster scaber, has neuroprotective effects, can prevent Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
1,5-Dicaffeoylquinic acid has antioxidant activity, and is stronger than that of ascorbic acid.
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The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
 Slanina J, Paulová H, Humpa O, et al. Organic Chem, 1999, 72.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: globe artichoke (Cynara scolymus), quince fruit (Cydonia oblonga), Caucasian whortleberry (Vaccinium arctostaphylos), Aster scaber and Ipomoea batatas (sweet potato) tubers
identification-method: Mass, NMR
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