Product correctly added to cart.

×
6-Shogaol

6-Shogaol

CAS 555-66-8

Ref. BP-BP0095

20mg
100mg
229.00 €
454.00 €
Estimated delivery time: ~13 days

Product Information

Name:
6-Shogaol
Synonyms:
  • 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

6- Shogaol can prevent secondary pathological events in traumatic Spinal cord injury (SCI) and promotes recovery of motor functions in an animal model raises the issue of whether shogaol could be used therapeutically in humans after SCI.[6]
6-Shogaol and 6-gingerol might both exert anti-invasive activity against hepatoma cells through regulation of MMP-9 and TIMP-1 and that 6-shogaol could further regulate urokinase-type plasminogen activity.[2]
6-Shogaol exerts its anti-inflammatory effects by inhibiting the production of prostaglandin E2 (PGE2) and proinflammatory cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), and by downregulating cyclooxygenase-2 (COX-2), p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-κB) expression; it shows significant neuroprotective effects in vivo in transient global ischemia via the inhibition of microglia, suggests that it is an effective therapeutic agent for treating neurodegenerative diseases.[3]
6-Shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER) stress signaling, affects the ER stress signaling by regulating unfolded protein response (UPR) sensor PERK and its downstream target eIF2α, thus, the PERK/eIF2α pathway plays an important role in 6-shogaol-mediated ER stress and apoptosis in SMMC-7721 cells in vitro and in vivo .[5]
6-Shogaol reduces the inflammatory response and protects the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats.[4]
6-Shogaol, an active constituent of ginger, is a potent inhibitor of MDA-MB-231 cell invasion, and the molecular mechanism involves at least in part the down-regulation of MMP-9 transcription by targeting the NF-κB activation cascade, thus has potential for clinical use as antimetastatic treatments. [1]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: grains of paradise (Amomum melegueta) and Zingiber officinale (ginger)
identification-method: Mass, NMR
type-of-compound: Phenols


Chemical properties

Molecular weight:
276.376
Formula:
C17H24O3
Purity:
98%
Color/Form:
Oil

Technical inquiry

Please use instead the cart to request a quotation or an order

If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.

Thank you!

Use of cookies

We use our own and third-party cookies to improve our services and show you advertisements related to your preferences by analyzing your browsing habits. You can get more information in our Cookies Policy .