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Alpinetin

Alpinetin

CAS 36052-37-6

Ref. BP-BP0160

20mg
100mg
186.00 €
303.00 €
Estimated delivery time: ~13 days

Product Information

Name:
Alpinetin
Synonyms:
  • 7-Hydroxy-5-methoxyflavanone
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

Alpinetin and cardamonin have vascular effects to relax rat mesenteric arteries through multiple mechanisms; they induce both endothelium-dependent and -independent relaxation, the former is likely mediated by nitric oxide whereas the latter is probably mediated through nonselective inhibition of Ca2+ influx and intracellular Ca2+ release and inhibition of the protein kinase C-dependent contractile mechanism.[3]
Alpinetin has anti-inflammatory properties, can activate PPAR-γ, thereby attenuate TLR4 expression and TLR4 mediated NF-κB and MAPK activation and the release of pro-inflammatory cytokines, suggests that it may be a therapeutic agent against inflammatory diseases. [4]
Alpinetin has antioxidant effects, can protect LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression.[5]
Alpinetin has antiproliferative effect in BxPC-3 pancreatic cancer cells possibly through the regulation of the Bcl-2 family and XIAP expression, release of cytochrome C and the activation of caspases, it may serve as a potential agent for the development of pancreatic cancer cell therapies.[2]
Alpinetin is a type of novel plant flavonoid derived from Alpinia katsumadai Hayata, possesses strong anti-hepatoma effects, can suppress HepG2 cell proliferation and arrested cells in the G0/G1 phase by up-regulating the expression levels of p-MKK7, and the antitumor effect of Alpinetin could be reversed by inhibiting the expression of MKK7; suggests that MKK7 may be a putative target for molecular therapy against hepatoma and Alpinetin could serve as a potential agent for the development of hepatoma therapy.[1]
Alpinetin suppresses T-cell-mediated delayed-type hypersensitivity reaction in mice, could shock the activation of NF-κB NFAT2 signal transduction pathways, indicates that it has potential effects in downregulating the immune system and might be developed as a useful immunosuppressive agent in treating undesired immune responses.[6]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Alpinia speciosa, Alpinia katsumadai, Chrysothamnus nauseosus, Helichrysum herbaceum, Dalea scandens, Alnus, Kaempferia, Eucalyptus and Piper spp.
identification-method: Mass, NMR
type-of-compound: Flavonoids


Chemical properties

Molecular weight:
270.284
Formula:
C16H14O4
Purity:
98%
Color/Form:
Powder

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