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×Emodin has a strong antimicrobial activity and anti-virus effect , can inhibit HBV DNA replication and HBsAg secretion in HepG2.2.15 cells, may be a new modality to treat hepatitis B infection. [2]
Emodin significantly inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced in vitro invasion of human cancer cells including HSC5 and MDA-MB-231 cells, and inhibits the invasiveness of human cancer cells by suppressing MMP-9 expression through inhibiting AP-1 and NF-kappaB signaling pathways.[3]
Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., exhibits anti-cancer effect on several human cancers such as liver cancers and lung cancers, treatment with 50 microM emodin resulted in a pronounced release of cytochrome c, activation of caspase-2, -3, and -9, and apoptosis in human lung adenocarcinoma A549 cells.[1]
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analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Present in Cascara sagrada (Rhamnus purshiana), in aloes Aloe spp., Rumex, Polygonum. and other plants. Penicillium spp., Aspergillus spp., Dermocybe sanguinea and Anixiella micropetrusa. First isol. in 1858
identification-method: Mass, NMR
type-of-compound: Anthraquinones
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