BRCA1 (phospho Ser1457) rabbit pAb
Ref. EK-ES7269
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
Chemical properties
Technical inquiry about: EK-ES7269 BRCA1 (phospho Ser1457) rabbit pAb
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