AG-825

CAS: 149092-50-2

Ref. TM-T14138

Product Information

• Name: AG-825
• Synonyms: Tyrphostin AG-825, (2E)-3-{3-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-4-hydroxy-5-methoxyphenyl}-2-cyanoprop-2-enamide, (E)-3-[3-[(2-Benzothiazolythio)Methyl]-4-Hydroxy-5-Methoxyphenyl]-2-Cyano-2-Propenamide, 2-Propenamide, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-, 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide, 4-Hydroxy-3-Methoxy-5-(Benzothiazolylthiomethyl)Benzylidenecyanoacetamide, 5-[(Benzothiazol-2-Yl)Thiomethyl]-4-Hydroxy-3-Methoxybenzyl-Idenecyanoacetamide, 5-[(Benzthiazol-2-Yl)Thiomethyl]-4-Hydroxy-3-Methoxybenzylidenecyanoacetamide, Tyrphostin Ag 825, Tyrphostin C15
• CAS: 149092-50-2

Description

AG-825(Tyrphostin C15) is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.AG-825 ( Tyrphostin C15) is a potentially active molecule for overcoming manganese-induced neurotoxicity or the development of Alzheimer's disease, and promotes apoptosis in human neutrophils, which could be used in the study of breast cancer.

• Brand: Targetmol

Chemical properties

• Molecular weight: 397.47
• Formula: C₁₉H₁₅N₃O₃S₂
• Purity: 98.43%
• Color/Form: Yellow Solid
• SMILES: COc1cc(/C=C(\C#N)C(N)=O)cc(CSc2nc3ccccc3s2)c1O