Procarbazine hydrochloride

CAS: 366-70-1

Ref. TM-T1488

Product Information

• Name: Procarbazine hydrochloride
• Synonyms: NSC-77213 HCl, Procarbazine HCl, 1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride, 2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride, 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide, 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide hydrochloride (1:1), Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1), Ibenzmethyzin hydrochloride, Ibenzmethyzine hydrochloride, Indicarb, MIH hydrochloride, Matulane, N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride, N-Isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride, NSC 77213, Nathulane, Natulan, Natulan hydrochloride, Natulanar, Nci-C 01810, PCB hydrochloride, Procarbazine HCL, Ro 4 6467/1, Ro 4-6467, p-Toluamide, N-isopropyl-α-(2-methylhydrazino)-, monohydrochloride
• CAS: 366-70-1

Description

Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

• Brand: Targetmol

Chemical properties

• Molecular weight: 257.76
• Formula: C₁₂H₁₉N₃O·HCl
• Purity: 98%
• Color/Form: (Ntp 1992)