Fludrocortisone acetate

CAS: 514-36-3

Ref. TM-T1666

Product Information

• Name: Fludrocortisone acetate
• Synonyms: 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate, 9α-fluorocortisol acetate, (11Beta)-9-Fluoro-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Acetate, (11β)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione, (8Xi,10Xi,13Xi,14Xi,17Xi)-9-Fluoro-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Acetate, 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate, 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate, 9-Fluorohydrocortisone acetate, 9-alpha-Fluorohydrocortisone acetate, 9-alpha-Fluorohydrocortisone-21-acetate, 9alpha-Fluorohydrocortisone 21-acetate, 9alpha-Fluorohydrocortisone acetate, 9α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione 21-acetate, 9α-Fluorocortisol 21-acetate, 9α-Fluorocortisol acetate, 9α-Fluorohydrocortisone 21-acetate, 9α-Fluorohydrocortisone acetate, Alflorone acetate, Brn 2067486, Cortef-F, Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate, Cortineff, Cortisol, 9-fluoro-, 21-acetate, F-Cortef acetate, Florinef, Florinef acetate, Fludrocortisone 21-acetate, Fludrocortisone acetate [JAN], Fluohydrocortisone acetate, Fluorhydrocortisone acetate, Fluorocortisol acetate, Fluorocortisone acetate, Fluorohydrocortisone acetate, Nsc 15186, Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11beta)-, Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-, Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate, Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-, 21-acetate (8CI), Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate, Scherofluron, U 4845, Unii-V47If0Pvh4
• CAS: 514-36-3

Description

Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

• Brand: Targetmol

Chemical properties

• Molecular weight: 422.49
• Formula: C₂₃H₃₁FO₆
• Purity: 98.03%
• Color/Form: Crystalline Solid