SN-38

CAS: 86639-52-3

Ref. TM-T1703

Product Information

• Name: SN-38
• Synonyms: NK012, SN 38, (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione, (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (S)-Sn 38, 10-Hydroxy-7-ethylcamptothecin, 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-, 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-, 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-, 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione, 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 7-Ethyl-10-Hydroxy Camptothecin, 7-Ethyl-10-Hydroxy-Camptothecine, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7-Ethyl-10-hydroxycamptothecine, Intermediate of Irinotecan 1, SN 38 (pharmaceutical), SN 38 lactone, Sn-38
• CAS: 86639-52-3

Description

SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.

• Brand: Targetmol

Chemical properties

• Molecular weight: 392.4
• Formula: C₂₂H₂₀N₂O₅
• Purity: 99.97%
• Color/Form: Light-Yellow Solid