Momelotinib
CAS: 1056634-68-4
Ref. TM-T1849
1mg | 38.00 € | ||
2mg | 49.00 € | ||
5mg | 80.00 € | ||
10mg | 93.00 € | ||
25mg | 163.00 € | ||
50mg | 254.00 € | ||
100mg | 399.00 € | ||
200mg | 612.00 € | ||
1ml*10 (DMSO) | 88.00 € |
Product Information
- CYT11387, CYT387, LM-1149
- Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-
- CYT 387 mesylate
- Cyt 11387
- Cyt-0387
- Cyt387
- Gs 0387
- N-(Cyanomethyl)-4-[2-(4-morpholinoanilino)pyrimidin-4-yl]benzamide
- N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
Chemical properties
Technical inquiry about: TM-T1849 Momelotinib
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