8-Chloroadenosine
CAS: 34408-14-5
Ref. TM-T19661
| 1mg | 73.00 € | ||
| 2mg | 94.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 247.00 € | ||
| 25mg | 418.00 € | ||
| 50mg | 573.00 € | ||
| 100mg | 820.00 € | ||
| 1ml*10 (DMSO) | 183.00 € |
Product Information
- NSC 354258, 8-Cl-Ado, NSC354258, NSC-354258
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.
Chemical properties
Technical inquiry about: TM-T19661 8-Chloroadenosine
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