GHN105
Ref. TM-T205672
Product Information
Name:GHN105
Brand:Targetmol
Description:GHN105 is an orally active STING inhibitor that suppresses STING-dependent IFN-β secretion in THP-1 human monocytes with an IC50 of 4.4 μM. In mice, GHN105 reduces serum levels of IFN-β, IL-6, and CXCL10, and alleviates colitis in a DSS-induced acute colitis mouse model. Additionally, GHN105 demonstrates favorable pharmacokinetic properties in mice, with an oral bioavailability of 43% and a half-life of 1.1 hours.
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Chemical properties
Molecular weight:800.89
Formula:C41H56N2O14
Color/Form:Solid
Technical inquiry about: GHN105
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