Negletein

CAS: 29550-13-8

Ref. TM-T2S0843

Product Information

• Name: Negletein
• Synonyms: 7-O-Methylbaicalein, Baicalein-7-methylether, Baicalein 7-methyl ether, 5,6-dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one
• CAS: 29550-13-8

Description

1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

• Brand: Targetmol

Chemical properties

• Molecular weight: 284.26
• Formula: C₁₆H₁₂O₅
• Purity: 99.92%
• Color/Form: Solid