S49076 HCl
CAS: 1265966-31-1
Ref. TM-T3512
| 5mg | 115.00 € | ||
| 10mg | 176.00 € | ||
| 25mg | 288.00 € | ||
| 50mg | 456.00 € | ||
| 100mg | 826.00 € |
Product Information
- S-49076 Hydrochloride
S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.
Chemical properties
Technical inquiry about: TM-T3512 S49076 HCl
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