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Crenigacestat
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Crenigacestat

CAS: 1421438-81-4

Ref. TM-T3633

1mg
60.00 €
5mg
118.00 €
10mg
184.00 €
25mg
346.00 €
50mgTo inquire
1ml*10 (DMSO)
119.00 €
Estimated delivery in United States, on Thursday 18 Apr 2024

Product Information

Name:
Crenigacestat
Synonyms:
  • LY3039478
Description:

Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, Crenigacestat inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.

Brand:
Targetmol
Long term storage:
Notes:

Chemical properties

Molecular weight:
464.44
Formula:
C22H23F3N4O4
Purity:
98.76%
Color/Form:
Solid
InChI:
InChI=1S/C22H23F3N4O4/c1-13(27-17(31)8-9-22(23,24)25)20(32)28-18-15-6-3-2-5-14(15)16-7-4-10-26-19(16)29(11-12-30)21(18)33/h2-7,10,13,18,30H,8-9,11-12H2,1H3,(H,27,31)(H,28,32)/t13-,18?/m0/s1
InChI key:
InChIKey=YCBAQKQAINQRFW-FVRDMJKUSA-N
SMILES:
C[C@H](NC(=O)CCC(F)(F)F)C(=O)NC1C(=O)N(CCO)c2ncccc2-c2ccccc21
MDL:
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HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: TM-T3633 Crenigacestat

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