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Picropodophyllotoxin

CAS: 17434-18-3

Ref. TM-T3S0027

1mg
38.00 €
5mg
80.00 €
10mg
93.00 €
25mg
177.00 €
50mg
287.00 €
100mg
433.00 €
1ml*10 (DMSO)
88.00 €
Estimated delivery in United States, on Thursday 18 Apr 2024

Product Information

Name:
Picropodophyllotoxin
Synonyms:
  • AXL 1717, Picropodophyllin
Description:

Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.

Brand:
Targetmol
Long term storage:
Notes:

Chemical properties

Molecular weight:
414.41
Formula:
C22H22O8
Purity:
99.57%
Color/Form:
Solid
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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