Sacubitril hemicalcium salt

CAS: 1369773-39-6

Ref. TM-T4200

Product Information

• Name: Sacubitril hemicalcium salt
• Synonyms: AHU-377 (hemicalcium salt), AHU377 calcium salt, (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt, (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt, AHU-377 hemicalcium salt, AHU377 Calcium salt, Sacubitril Hemicalcium, Sacubitril Hemicalcium salt, [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
• CAS: 1369773-39-6

Description

Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.

• Brand: Targetmol

Chemical properties

• Molecular weight: 861.06
• Formula: C₄₈H₅₆CaN₂O₁₀
• Purity: 99.28%
• Color/Form: Solid