Syk Inhibitor II dihydrochloride
CAS: 227449-73-2
Ref. TM-T4391
| 1mg | 128.00 € | ||
| 2mg | 207.00 € | ||
| 5mg | 447.00 € | ||
| 10mg | 638.00 € | ||
| 25mg | 929.00 € | ||
| 50mg | 1,240.00 € | ||
| 100mg | 1,661.00 € | ||
| 1ml*10 (DMSO) | 445.00 € |
Product Information
- Syk Inhibitor II (hydrochloride)
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
Chemical properties
Technical inquiry about: TM-T4391 Syk Inhibitor II dihydrochloride
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