SB297006
CAS: 58816-69-6
Ref. TM-T4674
| 5mg | 74.00 € | ||
| 10mg | 99.00 € | ||
| 25mg | 189.00 € | ||
| 50mg | 348.00 € | ||
| 100mg | 515.00 € | ||
| 1ml*10 (DMSO) | 76.00 € |
Product Information
- SB 297006
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
Chemical properties
Technical inquiry about: TM-T4674 SB297006
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