(±)-Praeruptorin A
CAS: 73069-25-7
Ref. TM-T4S1419
5mg | 59.00 € | ||
10mg | 94.00 € | ||
25mg | 172.00 € | ||
50mg | 257.00 € | ||
100mg | 369.00 € |
Product Information
- Praeruptorin A, (-)-Praeruptorin A
- (-)-Pareruptorin A
- Ccris 7247
- (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2Z)-2-methylbut-2-enoate
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
Chemical properties
Technical inquiry about: TM-T4S1419 (±)-Praeruptorin A
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