PF-5274857

CAS: 1373615-35-0

Ref. TM-T5465

Product Information

• Name: PF-5274857
• Synonyms: PF-5274857 freebase
• CAS: 1373615-35-0

Description

PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.

• Brand: Targetmol

Chemical properties

• Molecular weight: 436.96
• Formula: C₂₀H₂₅ClN₄O₃S
• Purity: 98.99%
• Color/Form: Solid
• InChI: InChI=1S/C20H25ClN4O3S/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28/h10-13H,4-9H2,1-3H3
• InChI key: InChIKey=BBVNTTZIOTWDSV-UHFFFAOYSA-N
• SMILES: Cc1cnc(-c2cc(N3CCN(C(=O)CCS(C)(=O)=O)CC3)ncc2Cl)c(C)c1