Barlerin

CAS: 57420-46-9

Ref. TM-T5S1632

Product Information

• Name: Barlerin
• Synonyms: 8-O-Acetylshanzhiside methyl ester, ND01, 8-Acetylshanzhiside methyl ester, 8-Acetylshanziside methyl ester, 8-O-Acetyl Shanzhiside Methyl Ester, 8-O-Acetylshanzhiside methyl ester, Cyclopenta[c]pyran-4-carboxylic acid, 7-(acetyloxy)-1-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5-hydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS)-, Cyclopenta[c]pyran-4-carboxylic acid, 7-(acetyloxy)-1-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5-hydroxy-7-methyl-, methyl ester, [1S-(1α,4aα,5α,7α,7aα)]-, Methyl (1S,4aS,5R,7S,7aS)-7-acetoxy-1-(beta-D-glucopyranosyloxy)-5-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate, O-Acetyl Shanzhiside Methyl Ester, 8-, Umbroside, cyclopenta[c]pyran-4-carboxylic acid, 7-(acetyloxy)-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5-hydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS)-
• CAS: 57420-46-9

Description

Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood-brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.

• Brand: Targetmol

Chemical properties

• Molecular weight: 448.42
• Formula: C₁₉H₂₈O₁₂
• Purity: 99.83%
• Color/Form: Solid