Tosedostat
CAS: 238750-77-1
Ref. TM-T6301
1mg | 54.00 € | ||
2mg | 70.00 € | ||
5mg | 128.00 € | ||
10mg | 202.00 € | ||
25mg | 412.00 € | ||
50mg | 603.00 € | ||
100mg | 860.00 € | ||
1ml*10 (DMSO) | 113.00 € |
Product Information
- CHR-2797
- alpha-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic acid cyclopentyl ester
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death.
Chemical properties
Technical inquiry about: TM-T6301 Tosedostat
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