Galeterone
CAS: 851983-85-2
Ref. TM-T6509
| 5mg | 56.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 138.00 € | ||
| 50mg | 227.00 € | ||
| 100mg | 369.00 € | ||
| 200mg | 554.00 € | ||
| 1ml*10 (DMSO) | 63.00 € |
Product Information
- VN-124-1, TOK-001, VN/124-1, VN 124
- (3beta)-17-(1H-BenziMidazol-1-yl)androsta-5,16-dien-3-ol
- (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol
- Androsta-5,16-dien-3-ol, 17-(1H-benzimidazol-1-yl)-, (3β)-
- Galaterone
- Tk-001
- Tok 001
- Vn 124
- Vn/124-1
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17, 20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.
Chemical properties
Technical inquiry about: TM-T6509 Galeterone
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