NSC697923
CAS: 343351-67-7
Ref. TM-T6611
| 5mg | 46.00 € | ||
| 10mg | 69.00 € | ||
| 25mg | 118.00 € | ||
| 50mg | 170.00 € | ||
| 100mg | 253.00 € | ||
| 500mg | 625.00 € | ||
| 1ml*10 (DMSO) | 50.00 € |
Product Information
- 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.
Chemical properties
Technical inquiry about: TM-T6611 NSC697923
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