Physalin B

CAS: 23133-56-4

Ref. TM-TN2063

Product Information

• Name: Physalin B
• Synonyms: NSC-287088, (1R,2S,5S,8S,9R,17R,18R,21S,24R,26S,27S)-5-Hydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.1~18,27~.0~1,5~.0~2,24~.0~8,17~.0~9,14~.0~21,26~]nonacosa-11,14-diene-4,10,22,29-tetrone, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16aR,17R,18aR)-2,3,6,6a,9,10,10a,14,16,16a-Decahydro-8a-hydroxy-2,6a,10b-trimethyl-17,3-(epoxymethano)-1,17:2,6-dimethano-17H-naphtho[1,2-f]furo[3,4-b:2,3-c′]bisoxocin-4,8,11,21(1H,8aH,10bH)-tetrone, 16,24-Cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid, 14,17:14,27-diepoxy-13,20,22-trihydroxy-1,15-dioxo-, γ-lactone δ-lactone, (14α,16β,22α,25S)-, 16α,24-Cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid, 14α,17:14,27-diepoxy-13,20,22-trihydroxy-1,15-dioxo-, γ-lactone δ-lactone, (20S,22R,24S,25S)-, 17,3-(Epoxymethano)-1,17:2,6-dimethano-17H-naphtho[1,2-f]furo[3,4-b:2,3-c′]bisoxocin-4,8,11,21(1H,8aH,10bH)-tetrone, 2,3,6,6a,9,10,10a,14,16,16a-decahydro-8a-hydroxy-2,6a,10b-trimethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16aR,17R,18aR)-
• CAS: 23133-56-4

Description

Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B ameliorates lipopolysaccharide-induced inflammatory response due to acute lung injury by inhibiting NF-κB and NLRP3 through activation of the PI3K/Akt pathway.Physalin B inhibits PDGF-BB-induced VSMC proliferation and migration and phenotypic transformation through activation of the Nrf2 pathway. Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation through activation of the Nrf2 pathway.Physalin B exerts antitumor activity by inhibiting LAP2α-HDAC1-mediated deacetylation of glioma-associated oncogene 1 and hepatic stellate cell activation.

• Brand: Targetmol

Chemical properties

• Molecular weight: 510.53
• Formula: C₂₈H₃₀O₉
• Purity: 98.40%
• Color/Form: Solid