- Angiogenesis
- Apoptosis
- BCL
- Chromatin/Epigenetics
- Cyclooxygenase (COX) Inhibitors
- Cytoskeletal Signaling
- Immunology and Inflammation
- Inhibitors
- IκB/IKK
- JAK
- JAK/STAT signaling
- Mmp and Impurities
- NF-κB
- NOS
- Neuroscience
- PI3K/Akt/mTOR Signaling
- Proteases/Proteasome
- STAT
- Stem Cell and Derivatives
- Stem Cells
- TNF
- Wnt/beta-catenin
- gsk-3
Product Information
- 2Methoxystypandrone
- 1,4-Naphthalenedione, 6-Acetyl-5-Hydroxy-2-Methoxy-7-Methyl-
- 2-Methoxy-6-acetyl-7-methyljuglone
- 6-Acetyl-5-hydroxy-2-methoxy-7-methyl-1,4-naphthalenedione
- Naphthoquinone (2-methylstipandrone
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.
Chemical properties
Technical inquiry about: TM-TN2775 2-Methoxystypandrone
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