- Angiogenesis
- Apoptosis
- Caspase
- Chromatin/Epigenetics
- Cytoskeletal Signaling
- DNA Damage/DNA Repair
- FAK
- G-protein Coupled Receptors and 7-TM Receptors
- GPCR/G-Protein
- Immunology and Inflammation
- Inhibitors
- JNK
- MAPK
- Mmp and Impurities
- NF-κB
- PI3K
- PI3K/Akt/mTOR Signaling
- Prostaglandin Receptor
- Proteases/Proteasome
- Stem Cell and Derivatives
- Stem Cells
- Tyrosine Kinase/Adaptors
- Wnt/beta-catenin
- gsk-3
Product Information
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
Chemical properties
Technical inquiry about: TM-TN4046 Excisanin A
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