- Apoptosis
- Cell Cycle/Checkpoint
- Cyclooxygenase (COX) Inhibitors
- DNA Damage/DNA Repair
- DNA/RNA Synthesis
- ERK
- G-protein Coupled Receptors and 7-TM Receptors
- GPCR/G-Protein
- HIV Protease
- IL Receptor
- Immunology and Inflammation
- Inhibitors
- JNK
- MAPK
- Microbiology/Virology
- NF-κB
- NOS
- Neuroscience
- Prostaglandin Receptor
- Proteases/Proteasome
- TNF
- p38 MAPK
Product Information
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.
Chemical properties
Technical inquiry about: TM-TN5011 Shizukaol B
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