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trans-Abacavir Dihydrochloride
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trans-Abacavir Dihydrochloride

CAS: 267668-71-3 783292-37-5

Ref. TR-A104995

1mg
348.00 €
25mg
1,823.00 €
50mg
2,894.00 €
Estimated delivery in United States, on Wednesday 22 May 2024

Product Information

Name:
trans-Abacavir Dihydrochloride
Synonyms:
  • (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride
Description:

Applications trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
359.25
Formula:
C14H18N6O· 2HCl
Color/Form:
White to Light Brown Solid
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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