Agmatine Sulfate

CAS: 2482-00-0

Ref. TR-A426900

Product Information

• Name: Agmatine Sulfate
• Synonyms: N-(4-aminobutyl)guanidine Sulfate, NIH 11035, (4-Aminobutyl)guanidine sulphate, (4-Aminobutyl)guanidinium sulfate, 1-(4-Aminobutyl)guanidine sulfate, 2-(4-Aminobutyl)Guanidine, 2-(4-Aminobutyl)Guanidine Sulfate, Agmatine Sulphate, Agmatine sulfate, Guanidine, (4-aminobutyl)-, sulfate (1:1), Guanidine, N-(4-aminobutyl)-, sulfate (1:1), Nih 11035
• CAS: 2482-00-0

Description

Applications General Uses: Neuroprotective, CNS studies, Autism and depression researchDescription:Agmatine Sulfate is a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats (2) and reverses depressive like behavior in mice. (3)
References Reis DJ, et al. 2000; Trends Pharmacol Sci. 2000 May;21(5):187-93 Kim JW, et al. 2016 Neuropharmacology. Sep 14;113(Pt A):71-81Neis VB, et al. 2016 Pharmacol Biochem Behav. Oct 12;150-151:108-114

• Brand: TRC

Chemical properties

• Molecular weight: 228.27
• Formula: C₅H₁₄N₄•H₂O₄S
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
• InChI key: InChIKey=PTAYFGHRDOMJGC-UHFFFAOYSA-N
• SMILES: N=C(N)NCCCCN.O=S(=O)(O)O