Product Information
Name:Aloisine A RP107
Controlled Product
Synonyms:
- 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
Brand:TRC
Description:Applications A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).References Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:267.33
Formula:C16H17N3O
Color/Form:Neat
InChI:InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
InChI key:InChIKey=PRIGRJPRGZCFAS-UHFFFAOYSA-N
SMILES:CCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12
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