N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide
Ref. TR-C227660
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued |
Product Information
Name:
N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide
Description:
Applications N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
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Chemical properties
Molecular weight:
462.379
Formula:
C21H17F3N4O5
Color/Form:
Grey Solid
InChI:
InChI=1S/C21H17F3N4O5/c22-12-6-14(23)13(15(24)7-12)8-25-19(30)17-18(29)20(31)28-16(27-17)9-26-21(32)33-10-11-4-2-1-3-5-11/h1-7,29H,8-10H2,(H,25,30)(H,26,32)(H,27,28,31)
InChI key:
InChIKey=HENYZYQASSRBQZ-UHFFFAOYSA-N
SMILES:
O=C(NCc1nc(C(=O)NCc2c(F)cc(F)cc2F)c(O)c(=O)[nH]1)OCc1ccccc1
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