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CTOP
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CTOP

CAS: 103429-31-8

Ref. TR-C800010

Estimated delivery in United States, on Tuesday 26 Oct 2021

Product Information

Name:
CTOP
Synonyms:
  • 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane Cyclic Peptide Deriv.
  • D-​Phenylalanyl-​L-​cysteinyl-​L-​tyrosyl-​D-​tryptophyl-​L-​ornithyl-​L-​threonyl-​3-​mercapto-​L-​valyl-L-​threoninamide Cyclic (2→7)​-​Disulfide
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7)
  • N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-10-(3-aminopropyl)-16-(4-hydroxybenzyl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-19-(phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
Description:

Applications CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
References Fraga de Santana, M. et al.: Pharm. Biol., 53, 1583 (2015);

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Chemical properties

Molecular weight:
1062.26
Formula:
C50H67N11O11S2
MDL:
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
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LQ:

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