De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride

CAS: 1000690-91-4

Ref. TR-D215505

Product Information

• Name: De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride
• Synonyms: Cetirizine Dihydrochloride Imp. B (EP), Cetirizine Imp. B (EP), (RS)-2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]acetic Acid Dihydrochloride, Cetirizine Dihydrochloride Imp. B (EP) as Dihydrochloride, Cetirizine Dihydrochloride Impurity B as Dihydrochloride, Cetirizine Impurity B as Dihydrochloride

Description

Applications De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride, is an impurity of Cetirizine (C281100, 2HCl); a nonsedating type histamine H1-receptor antagonist and a major metabolite of Hydroxyzine (H996500). Pharmacological activity of Cetirizine resides primarily in the (R)-isomer. Also antihystaminic.
References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987); Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987); Fadel, R., et al.: Clin. Allergy, 17, 373 (1987); Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

• Brand: TRC

Chemical properties

• Molecular weight: 417.76
• Formula: C₁₉H₂₁ClN₂O₂•2HCl
• Color/Form: White
• InChI: InChI=1S/C19H21ClN2O2.2ClH/c20-17-8-6-16(7-9-17)19(15-4-2-1-3-5-15)22-12-10-21(11-13-22)14-18(23)24;;/h1-9,19H,10-14H2,(H,23,24);2*1H
• InChI key: InChIKey=NBQBQRKLQXVPIS-UHFFFAOYSA-N
• SMILES: O=C(O)CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1